Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 6 Articles
Purpose: The aim of this work was to describe the epidemiological, clinical\nand therapeutic features of pigmented skin acne in Benin. Methods: This was\na prospective, cross-sectional and analytical study conducted in the dermatology\ndepartments of the Borgou-Alibori Departmental Teaching Hospital\nand the National Teaching Hospital Hubert Koutoukou Maga from January\n2017 to December 2018, which has included black-skinned patients who were\ndiagnosed with acne and gave their free and informed consent. The ECLA\nscore was used for clinical evaluation of the severity of the acne. Results: We\ncollected 129 patients including 35 men and 94 womenâ?¦..............................
Background: Although vitiligo shows a similar clinical picture to other disorders\nin which patients exhibit depigmented spots, there are few reports on\nthe differentiation of these conditions from each other. Purpose: We aimed to\ninvestigate the differences and similarities between vitiligo and nevus depigmentosus\nin children based on the clinical course and characteristics. Materials\nand Methods: We conducted an examination of the disease type, treatment,\nprogress, and differentiation of 85 cases of vitiligo and nevus depigmentosus\nthat developed before 15 years of age among patients who visited\nthe Osaka University Department of Dermatology with a chief complaint of\nwhite patches from January 2010 to March 2017. Results: The median age at\nthe onset of symptoms of 79 patients with vitiligo was 4.5 years and while that\nof 6 patients with nevus depigmentosus was 0.8 years, indicating that the onset\nof nevus depigmentosus occurred earlier. While vitiligo often developed in\nthe head and neck regions, with a tendency for depigmented spots in multiple\nregions, nevus depigmentosus did not show this tendency in these regions.\nUpon performing Woodâ??s lamp observation in 38 cases of vitiligo, 35 cases\nwere found to be fluorescent chalky white and in 3 cases histologically diagnosed\nas vitiligo, no clear fluorescent color was observed. All 6 patients diagnosed\nwith nevus depigmentosus exhibited a non-fluorescent off-white color\nunder a Woodâ??s lamp. Conclusions: This study indicates that non-invasive\nobservation using a Woodâ??s lamp is useful in the differential diagnosis of pediatric\nleukoderma, in addition to the subsequent clinical course, such as the\npresence or absence of lesional repigmentation and/or enlargement....
Background. Noncultured epidermal suspension (NCES) is a surgical technique which employs cellular grafting onto depigmented\nlesions. However, scarring and dyschromia at the donor site often occurs. Objective. To assess the outcome of reusing the same donor\nsite in subsequent sessions of NCES procedures. Methods. Electronic records of vitiligo patients who had undergone two sessions of\nNCES procedures were retrospectively reviewed. Information on the first and second NCES was retrieved for analyses. Results. A total\nof 30 patients (female 19 and male 11) were included. The majority of patients had nonsegmental vitiligo (66.7%). The median donorto-\nrecipient ratios were .................................
Objective. To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their\nrelevant factors, as well as the relationship between child growth and propranolol. Methods. A total of 506 patients with confirmed or\nsuspected IHs were enrolled, and a total of 439 cases were included in the study. Short-term AEs were analysed using single-factor\nanalysis and binary logistic regression. Out of 439 patients, 292 were enrolled to examine the effect of propranolol on 2-year-oldsâ??\nheight and body weight (BW), by comparison with reference range and among groups. Spearman rank correlation analysis was\nused to determine the relationship between BW, height, and duration of propranolol treatment. Results. Among 439 patients, 70\n(16.0%) experienced AEs. Among them, 48 had gastrointestinal (GI) symptoms, 23 had central nervous system (CNS) symptoms,\n8 had both symptoms above, and 7 had other symptoms. ......................................
Sweetâ??s syndrome is an uncommon skin disease characterized by painful polymorphic\nlesions associated with fever and neutrophilia. When biopsied, these lesions reveal a diffuse infiltrate\nof mature neutrophils in the papillary dermis. Several drugs can induce Sweetâ??s syndrome (so-called\ndrug-induced Sweetâ??s syndrome (DISS)) but reports of DISS associated with hydroxychloroquine\n(HCQ) are exceptionally limited. A 72-year-old Caucasian female patient with elderly-onset primary\nSjogrenâ??s syndrome (EOpSS) but low disease activity presented with an abrupt onset of painful\nnodular and papular erythematous skin lesions after two weeks of therapy with HCQ 400 mg. A\nhistological examination revealed a diffuse infiltrate of mature neutrophils in the papillary dermis,\nwithout vasculitis. After therapy with 25 mg/day prednisone and HCQ withdrawal, the cutaneous\nmanifestations disappeared. When prednisone was permanently discontinued, the primary Sjogrenâ??s\nsyndrome (pSS) manifestations worsened and therapy with HCQ 200 mg was reintroduced. In a\nfew days, the same skin lesions reappeared. Withdrawal of HCQ and a new cycle of prednisone\nresulted in their permanent disappearance. We reported a case of DISS following therapy with HCQ\nin a female patient affected by EOpSS. According to a literature review, this is the first report of\nthis association....
Cutaneous squamous cell carcinoma (SCC) is a common cancer that significantly decreases the quality of life. It is known that\nexternal stimulus such as ultraviolet (UV) radiation induces cutaneous SCC via provoking oxidative stress. NAD(P)H dehydrogenase\n1 (NQO1) is a ubiquitous flavoenzyme that functions as a guardian against oxidative stress. However, the effect of\nNQO1 on cutaneous SCC is not clearly elucidated. In this study, we investigated the effect of NQO1 on cutaneous SCC cells using\nthe recombinant adenoviruses that can upregulate and/or downregulate NQO1 expression. Overexpression of NQO1 resulted in\nsignificant decrease of cell proliferation and colony forming activity of SCC lines (SCC12 and SCC13 cells). By contrast,\nknockdown of NQO1 increased the cell proliferation and colony forming activity. Accordingly, the levels of proliferation-related\nregulators, such as Cyclin D1, Cyclin E, PCNA, SOX2, and p63, were decreased by the overexpression of NQO1, while those were\nincreased by knockdown of NQO1. In addition, NQO1 affected the invasion and migration of SCC cells in a very similar way, with\nthe regulation of epithelial-mesenchymal transition- (EMT-) related molecules, including E-cadherin, N-cadherin, Vimentin,\nSnail, and Slug. Finally, the overexpression of NQO1 decreased the level of phosphorylated AKT, JNK, and p38 MAPK, while the\nknockdown of NQO1 increased the level of phosphorylated signaling molecules. Based on these data, NQO1 has tumor suppressive\nfunction in cutaneous SCC cells....
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